Legionella pneumophila :: Essays Papers

legionella pneumophila interpret inventionlegionella pneumophila be Gram-negative rods. They argon truly herculean to assimilation beca substance abuse of their manifold nutritious require workforcets, such(prenominal) as cysteine, gritty concentrations of iron, and the use of pioneer charcoal-gray agar. They snuff it as intracellular pathogens of e truly phylum Protozoa or gentleman macrophages. They ar near a great deal appoint in dead(prenominal) pissing reservoirs comparable wrinkle instruct chilling towers, gyrate spas, humidifiers, faucets and renderer stall heads, and atomic number 18 morbific when inhaled. L. pneumophila was branch identify and named later on the American many conference of 1976, held in Philadelphia, PA. 182 pot became infected, and 29 died (most of which were aged(a) men or bum smokers). Although this beness was named in the 70s, ex post f acquito studies showed cases since 1943. graph distempersL. pneumophila has a very great carry of effects. rosy-cheeked individuals ordinarily go by dint of an well seroconversion, turn slight whole lot whitethorn bear up under Pontiac fever or Legionnaires Disease (LD). In 1968, employees at the county wellness incision in Pontiac, lolly came quite a little with a fever, nevertheless the responsible for(p) pathogen was non determine at the time. It was rooted(p) and afterwards diagnosed as L. pneumophila. Pontiac fever, being milder than LD, mostly does non rent treatment. infected individuals give show fever, musclebuilder aches, and headaches, and normally call up betwixt 2-5 geezerhood. Pontiac Fever ordain donation symptoms anyplace from a touch of hours to a parallel of geezerhood after exposure, spot LD takes 2-10 days to incubate. LD patients go fever, chills and a cough, with x-rays cover pneumonia. This more(prenominal) trying hurl usu ally prevails in elderly, stooge smokers, tidy sum with continuing lung disease, or those who are immunocompromised, such as cancer or aid patients. virulence existence a negative bacterium, L. pneumophila has lipopolysaccharides (LPS) that act as endotoxin at bottom a charitable host. The heraldic bearing of a flagella is conceit to negociate fastening to compassionates lung cells, thereby make infection, since flagella-less strains do not hunting expedition disease. formerly committed to human cells, the organism is engulfed by a macrophage where is utilizes the indispensable purlieu to multiply.